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NCCAOM Video Contest
The NCCAOM is excited to announce the launch of the second annual video contest "Because it Works!" 2015.
Free Yourself From the Pocketbook Practice
Let's take a journey together; there's an important lesson to be learned. Imagine a town or city just like yours.
News in Brief
Investigating the Cellular Impact of Mechanical Force; National Board Seats (Not-So) New Officers at Annual Meeting.
Integrative Medicine for the Underserved: A Seat at the Table
Numerous organizations have risen to the challenge of providing care to medically-underserved populations and here we feature one such group.
Chinese Doctors Poke Holes in Australian Study
A recent Australian clinical trial, published in the Journal of the American Medical Association (JAMA) in 2014 by Rana Hinman, et el., evaluating the effectiveness of both needle and laser acupuncture for chronic knee pain.
The Source-Luo Point Combination, Part 2
The Da Cheng includes symptoms for the source-luo points that indicate when to use them for treatment. Yang defines the method as the guest-host (it is one of a variety of acupuncture point combinations called guest-host).
An International Life: An Interview with Mary Elizabeth Wakefield
I met Mary Elizabeth Wakefield during her class last summer in Seneca Falls, New York at the Finger Lakes School of Chinese Medicine.
Q&A With the First VA Chiropractic Residents
As you may have read previously, a major step forward for the profession occurred in July 2014 when the Department of Veterans Affairs began piloting a chiropractic residency program at five locations.
Going On-Site With Chiropractic Care
The Foundation for Chiropractic Progress has released a position paper highlighting the financial, clinical and patient-satisfaction benefits of providing chiropractic care at on-site corporate health clinics.
Key Changes and Updates to the 7th Edition CNT Manual
Acupuncture Today recently interviewed Jennifer Brett, ND, L.Ac. regarding the updates to the CNT manaul.
Creating Relationships at Southwest Symposium
The month of May brought many interesting activities. As I have said in many previous columns this year, this profession is moving in a very exciting direction. Make sure you are getting involved. If you're not, you just might get left behind.
The Risks I Took
We all take risks when we choose this profession. For some, it is not knowing if you can make a living practicing TCM. For others, it is parental or cultural disapproval.
I was sitting in a Pizza Hut in Peoria, Ill., with my friend Reggie, sometime in the spring of my senior year in college, when he started doodling on his paper placemat. In those days, the company had a picture of U.S. on the mats, showing all the locations of the "Huts" in the country.
The Three Heater Official
This Official, belonging to the element Fire, is responsible for maintaining and regulating the heating system of the body, mind, and spirit. It is named for its function. The trunk is divided into three "burning spaces" or "jiaos."
Leg-Length Inequality and Pelvic Fixation: A New Approach to the Negative Derifield (Part 3)
A patient with sacroiliac fixation and dysfunction ordinarily demonstrates a noticeable leg-length inequality when placed in the prone position on the adjusting table.
Marketing with a Microphone
When given an option, it stands to reason that people prefer to do business with those they know, like, and trust.
Sports Medicine 101: Surgery or No Surgery?
In the world of sports medicine, many careers are saved by surgeries that correct traumatic damage to the body. Muscle tears, ligament damage, fractures, spinal disc herniations, and joint instabilities are a few of the issues frequently addressed with surgical intervention.
Desert: A Metaphor from the Study of Genetics
In most of the human lives I know about, there are stretches of time which feel stagnant, or worse. We can feel adrift, or wounded and sidelined, and these times don't seem to carry much usefulness while they are unfolding.
Nomenclature and Classification of Lumbar Disc Pathology: Version 2.0
The Nomenclature and Classification of Lumbar Disc Pathology consensus, published in 2001 by the collaborative efforts of the North American Spine Society, the American Society of Spine Radiology and the American Society of Neuroradiology, has guided radiologists, clinicians and the public for more than a decade.
Treatment of PTSD: An Opportunity for the Practice of Integrated Medicine
PTSD is widespread across America today. Not only do many of our honored men and women in uniform bring it home with them from the war zones they have been active in, but it often follows any life-threatening event people go through when their lives have been in danger.
Meet Cheyenne: Your Future Colleague
Allow me to introduce you to Cheyenne (Chey), the daughter of some of our family's closest friends. We attend and serve at the same church together, and have known each other for many years.
Should You Change an Athlete's Natural Running Form?
Once past the ankle, impact forces travel at about 200 mph into the knee. In addition to allowing the quad to absorb force, bending the knee (E) prevents the hip and pelvis from moving up and down too much (F), which is important for injury prevention and efficiency.
August, 2005, Vol. 05, Issue 08
The Natural Effects of Melatonin
By John Upledger, DO, OMM
As manual therapists, it's vital that we continue to study the human organism - inside and out - to fully understand our role in helping individuals achieve optimal health and well-being.As part of that quest, I've been researching a helpful natural chemical called melatonin. This lipophilic indole, chemically known as 5-methoxy-N-acetyl-tryptamine, is a derivative of serotonin, which in turn is derived from the amino acid tryptophan.
Until recently, researchers thought melatonin was secreted only by the pineal gland. Since it was synthesized within and secreted by a gland, it became known as a hormone. Scientists have also speculated that melatonin was only secreted at night and primarily to induce sleep, and that artificial light could reduce the amount of melatonin secreted by the pineal gland. Since then, we've learned a lot more about the powers of melatonin. Yes, it's confirmed: The pineal gland is a major source of melatonin, which does indeed induce sleep. And yes, when the eyes take in artificial light, sleep is somewhat inhibited.
About 30 years ago we discovered that the appendix also generously synthesizes and secretes melatonin, which suggested that appendectomies might reduce melatonin levels. We've since found out that melatonin is also produced by the intestines, the fundus of the stomach, the testes, the spinal cord, the raphe nuclei of the brain stem, and the striatum areas of the brain. We now also understand that a significant amount of melatonin is synthesized within the body cells. Many of these melatonin molecules do not even leave their cells of origin, but instead remain inside them to protect them from being damaged by oxygen and nitrogen radicals and other toxicants.
You might even call melatonin a "double whammy" protector. After it neutralizes damaging reactive species, the metabolites that are produced in the process are even more effective at protecting the cells than the original melatonin molecules. In general, melatonin seems especially protective of DNA inside the nuclei and mitochondria. It also protects cell-membrane lipids and cytosol-contained proteins.
Personally, I believe every cell in our body contains some melatonin, whether it was produced in that cell or, less likely, entered through extracellular body fluids. Yet there are also other sites in the body with high levels of melatonin. The level of melatonin in the bile of the liver and gallbladder exceeds that of the blood and bone marrow. And the level of melatonin in cerebrospinal fluid (CSF) is much higher than that of the blood. In the CSF, melatonin is greatest in and around the third ventricle of the brain, probably because of the pineal-gland secretions. CSF melatonin levels are also greater at night, as is the pineal gland's production of melatonin. It's also interesting to note that the fluid in the Graafian follicle is higher than the blood level of melatonin.
Now let's look at some of the positive effects melatonin offers in specific dis-ease processes. Probably most important at this time is the fact that melatonin reduces degenerative activities in the brain, spinal cord and spinal nerve roots. Degeneration of these nerve tissues and cells often occur from the effects of reactive oxygen species and reactive nitrogen species, as well as excessive or prolonged inflammation.
Beta amyloid peptides (BAP) are metabolic byproducts of the degradation of amyloid precursor proteins (APP). When these proteins (which are normally part of cell membranes) are metabolized as they wear out and lose their functional abilities, they break down into BAP. When these peptides aren't effectively cleared away by the natural flushing of CranioSacral Therapy (CST) or other fluid-moving techniques, they can form plaques and tangles that cause neuronal dysfunction and death. The result? Increased tissue inflammation that leads to cerebral and/or spinal cord degeneration. The name of any resulting disease depends on the location of the degeneration. When it takes place in the hippocampus and cerebral forebrain, it's called Alzheimer's disease. When it takes place in the lower aspect of the brain (the substantia nigra), it's called Parkinson's disease.
Melatonin helps by neutralizing BAP to keep the peptides from forming disease-producing plaques and tangles. It also removes metals that may be involved in the plaques and tangles. These metals include cobalt (often found at higher levels with Alzheimer's disease) and aluminum. Occasionally, high levels of iron may damage the brain or spinal cord, while excessive copper may affect the central nervous system (CNS) in a similar way. Melatonin removes excess iron and copper as needed.
On the opposite side of the fence, melatonin may link up with zinc. This combination seems to enhance thymus-gland function and the whole immune system secondarily. When CNS neurons have been damaged, melatonin also promotes the production of neuronal growth factor, which may help reestablish neuronal circuits that have been injured or interrupted. (I have also had success dialoging with stem cells and getting them to replace damaged or dead neurons as needed.)
Other conditions I believe to be helped by melatonin: stroke damage; damage due to ionizing radiation; diabetic neuropathy; heavy-metal toxicities; non-metallic toxicities; viral infections; seizures; excitotoxicities; homocysteine damage; ischemic damage; reperfusion injury; degenerative CNS diseases, such as Alzheimer's, Parkinson's, multiple sclerosis, amyotrophic lateral sclerosis, senility and so on.
From a therapeutic perspective, I've found the following tactics helpful in enhancing melatonin effectiveness:
* I administer these in divided doses as tolerated by the client. Please note: The information presented here is strictly intended for educational purposes only, and is not to be construed as medical advice.
By continuing to explore the valuable role of melatonin in our bodies and by learning tools to enhance its effectiveness through complementary care, we give our clients more opportunities to enjoy good health, naturally.
Click here for previous articles by John Upledger, DO, OMM.
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